Osteogenesis Imperfecta (Their Rare Genetic Condition Explained & What They’ve Said About It)
Jay & Pamela shares the journey of a young couple living with Osteogenesis Imperfecta Type III. The show follows Jay Manuel and Pamela Chavez through their daily lives, which includes running errands and living with Jay’s family and their dog, Cheddar. TLC has aired several other shows exploring the lives of little people, like Seven Little Johntons; however, this is the first show about people with OI.
Because of their condition, tasks tend to take more time or require extra caution. However, Jay and Pamela must do the same day-to-day activities as everyone else. Whether they are meal planning or visiting with friends, the show gives viewers a glimpse of what life is like for them.
Jay And Pamela Have Osteogenesis Imperfecta Type III
There Are 19 Types Of OI
As Jay and Pamela explain early in the first episode, they have a condition called Osteogenesis Imperfecta Type III. While the couple do not go into detail about other types of OI, the viewer can tell by Pamela’s tone that distinguishing Type III from other types is significant. This may leave the viewer wondering about other types of OI.
While there are 19 types of OI in total, according to Cleveland Clinic, the first four types are the most common. All types of OI are caused by a genetic mutation and affect the body’s ability to produce collagen in bones, causing them to become prone to breaking. The severity and prognosis varies significantly from type to type.
OI Type III Is One Of The Most Severe
Jay and Pamela Experience Frequent Broken Bones And Other Health Issues
Jay and Pamela’s condition, OI Type III, is very severe. As Jay and Pamela explain to viewers, they do not produce enough collagen, which causes their bones to be more hollow. Since their bones are weak, they are at risk of fracturing their bones doing everyday activities. Because of this, they must be very cautious to avoid falls or accidents, as even a minor one could cause an issue.
Pamela gave an example of her suffering a leg fracture from falling out of her wheelchair because she tried to reach something too far away.
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Like many individuals with OI Type III, Jay and Pamela require the use of a power wheelchair. While they can use a standard wheelchair, they would need to rely on someone to push them. A power wheelchair allows them to have more independence. Because they are of short stature, Jay and Pamela also use a grabbing tool to reach items without leaning out of their chairs. The couple also have a modified shower in their bathroom which allows them to move directly from their chairs to avoid injury.
OI Is Caused By A Genetic Mutation
It Can Be Random Or Inherited
All types of OI are caused by genetic mutation, meaning they cannot be prevented, and people are born with the condition. Severe types, like type III, are apparent at birth, and some babies are even born with broken bones. Both Jay and Pamela were diagnosed as babies with this very rare condition, so they have always been aware of their OI diagnosis.
While the condition can be inherited from parents, it is common for OI to be caused by a random genetic mutation. Since neither Jay’s nor Pamela’s parents have OI, it is due to a random mutation for both of them. Jay’s parents, Rafael and Rene, explain they were not expecting the diagnosis, and it was difficult to adjust to the news. However, they both embraced Jay for who he is and seem to be very loving, supportive parents.
OI Affects The Whole Body
Jay And Pamela Have Restricted Mobility And Are At Risk Of Blood Clots
Since OI affects the structure of all bones, the whole body is impacted. Growth restriction is one of the impacts. OI Type III can cause scoliosis, so it is common to have a curved back, which can make them appear even shorter. Jay and Pamela are 3’3″ and 3’4″; however, they don’t remember which one is the taller one. As Jay says:
Either way, we’re short, so it doesn’t make a difference.
Blood clots are a major concern for people with OI type III. Because they have a small chest cavity, it is more likely for them to develop clots and have the clots get stuck in their lungs, which can be fatal. Another more common concern is constipation. In episode 3, Jay is hospitalized due to constipation. Even though it is relatively routine for those with OI type III to require a few days in the hospital when constipated, hospitalization always increases the worry that a more severe problem could occur.
While Jay is hospitalized, his heart rate spikes. Pamela becomes very worried, as one of Jay’s friends who also had OI, passed away from a heart condition. Jay tries to reassure Pamela that his heart rate is elevated only because he is feeling unwell, but because there are so many risks that come with OI, her concern is understandable. The conclusion of episode 3 leaves fans wondering if Jay will be okay, as he is still in the hospital.
Jay and Pamela Defy Odds
Despite A Grim Prognosis, They Are Thriving
According to the Osteogenesis Imperfecta Foundation, the life expectancy of OI Type III varies. While some people with OI may live a normal lifespan, some pass away during childhood or adulthood, because of the increased risk of blood clots or other severe complications. Jay’s parents were told he would not live past five years, and Pamela’s parents were told she would not make it past age one, but Jay is now 28, and Pamela is 30. However, they acknowledge they are considered to be on the older side of the OI Type III community.
One of the most touching parts of the show is seeing how close of a bond the couple have with their dog, Cheddar.
Despite their doctors’ initial predictions, Jay and Pamela are thriving. Jay and Pamela both work from home and are saving up to move out of Jay’s parents’ house and get a place of their own. Jay’s father, Raphael, is teaching Pamela how to cook, and Jay’s mother, Rene, is encouraging them to be more independent. Jay and Pamela are great dog parents. One of the most touching parts of the show is seeing how close of a bond the couple have with their dog, Cheddar.
The most exciting item on Jay and Pamela’s agenda is their upcoming wedding. They have found an accessible venue which will allow them to be comfortable on their big day. Pamela’s dress is being altered to add more flair and ensure it fits well. The couple is also taking dance lessons to prepare for their first dance. With so much excitement, fans can anticipate a fun season of Jay & Pamela getting to know the couple.
Jay & Pamela airs Tuesdays at 10 p.m. EST on TLC.
Source: Cleveland Clinic; Pamela Chavez/Instagram, Osteogenesis Imperfecta Foundation
Jay & Pamela
- Release Date
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March 4, 2025
